Triggering condition by number of events or observations of an endpoint

Define a condition to trigger trial milestone by the number of events of a time-to-event endpoint or the number of non-missing observations of a non-time-to-event endpoint. The milestone will be triggered when a trial has observed at least the specified number of endpoint events (or non-missing observations). It can be used combined with conditions specified by calendarTime and enrollment.

Number of events for a time-to-event endpoint can vary at different milestones as more patients are randomized into a trial, or more events onset over time.

Number of non-missing observations for a non-time-to-event endpoint can vary at different milestones as more patients are randomized into a trial, or more patients have been treated until their readout time (thus, NA turns to a value).

Usage

eventNumber(endpoint, n, arms = NULL)

Arguments

endpoint: character. Name of an endpoint.
n: integer. Targeted number of events.
arms: vector of character. Name of arms on which the number of events is counted. If NULL, use all arms that are not yet removed from the trial by the time of calculation.

Value

an object of class `Condition`