Support inclusion criteria in arm through the ... argument.
TrialSimulator 0.73.0
New Feature
Print summary report of arms when printing an arm object in console or rmarkdown.
TrialSimulator 0.72.0
New Feature
Print summary report of endpoints when printing an endpoint object in console or rmarkdown.
TrialSimulator 0.70.0
Updates
Add vignette for longitudinal endpoints.
TrialSimulator 0.68.0
Updates
Rename trial event as milestone. This a major update. Relevant codes and documents are updated accordingly.
Add executable examples for controller() as per suggestion from CRAN team.
TrialSimulator 0.67.0
Updates
Print event counts at trial events using message() so that Shiny app can display it properly.
TrialSimulator 0.66.0
Updates
Add cases for unit test.
TrialSimulator 0.65.0
New Features
Add function solveMixtureExponentialDistribution to compute median of exponential endpoint of subgroup or the overall population.
TrialSimulator 0.63.0
New Features
Add wrapper functions endpoints, arm, trial, event, listener and controller for Endpoint$new, Arm$new, Trial$new, Event$new, Listener$new and Controller$new.
TrialSimulator 0.62.0
New Features
Allow extending trial duration with Trial$set_duration.
TrialSimulator 0.61.0
Updates
Deprecate function enroll_a_patient. Use enroll_patients only.
TrialSimulator 0.58.0
Updates
Update vignette of adaptive seamless design.
Bug Fixes
Fix a bug to use n > 1 in Controller$run when an arm can possibly be removed adaptively during a trial.
New Features
Allow specifying arms in enrollment. This is useful to count randomized patients of all arms even if some are removed adaptively.
TrialSimulator 0.57.0
Updates
Move vignette of comparison between GraphicalTesting and graphicalMCP to repository TrialSimulatorDocuments.
TrialSimulator 0.56.0
New Features
Controller$run now can specify number of simulation replicates by newly added argument n. If n is greater than 1, simulation results can be accessed in Controller$get_output().
TrialSimulator 0.55.0
Bug Fixes
Fix a bug in StaggeredRecruiter to force the enrollment time of the first patient is zero. This is an known issue but I was too lazy to fix it. Earlier version may have overestimated time of events.
New Features
add function fitFarringtonManning of Farrington-Manning test for rate difference.
TrialSimulator 0.54.0
New Features
Add function Trial$bind to row bind data frame in action functions. It is useful to prepare inputs of group sequential or graphical test.
TrialSimulator 0.53.0
New Features
Add vignette of condition system.
TrialSimulator 0.52.0
Bug Fixes
Fix a bug that data is not censored correctly at events. This bug does not affect a trial without interims.
TrialSimulator 0.51.0
New Features
Add vignette of non-time-to-event endpoints.
Add function weibullDropout to compute parameters of Weibull distribution when using it for dropout distribution.
TrialSimulator 0.49.0
New Features
Add vignette of time-to-event endpoints.
TrialSimulator 0.48.0
Bug Fixes
Fix a bug when alpha of a node in graph is set to rounding error bound 1e-5 while no alpha should have been propagated.
TrialSimulator 0.47.0
New Features
Support new condition system for event triggering. Built-in functions enrollment, eventNumber and calendarTime can be combined with & and |. Nested combination is supported by using parentheses.
TriggerByEventNumbers and TriggerByCalendarTime are therefore deprecated.
TrialSimulator 0.44.0
Bug Fixes
Fix a bug when adding an arm that is already in the trial.
TrialSimulator 0.43.0
New Features
Add function fitLogistic to fit logistic regression model.
Support model fitting for multiple treatment arms in logistic regression, Cox PH model, and logrank test.
TrialSimulator 0.42.0
Minor Updates
Add a logo.
TrialSimulator 0.40.0
Bug Fixes
Revise examples for CRAN submission.
TrialSimulator 0.39.0
Bug Fixes
Remove space in class name to eliminate R CMD check note.
TrialSimulator 0.38.2
Bug Fixes
Throw error message when none of the hypotheses at test has non-zero alpha in graphical test.
Update vignette.
TrialSimulator 0.38.1
New Features
Plot stacked area chart for accumulative event numbers of endpoints.
Bug Fixes
Fix a bug when small weight (epsilon) is used in graph in graphical testing. Small weight can be conflict with integral tolerance error.
TrialSimulator 0.37.0
New Features
Return more informative error message when custom random number generators are used to define endpoints. Specifically, it guides users to return columns for time-to-event endpoints properly.
Update manual for generator in Endpoint.
TrialSimulator 0.36.0
Bug Fixes
Fix a bug in GraphicalTesting when a hypothesis is tested multiple times at the same stage because more alpha is passed from other rejected hypothesis.
TrialSimulator 0.35.0
New Features
Warn when incremental information is too low that can affect normality approximation of combination test.
Bug Fixes
Minor bugs fixed.
TrialSimulator 0.33.0
New Features
Add README.
TrialSimulator 0.33.0
New Features
Provide a default action function do_nothing() if users have no intent to do anything at a triggered event. This function can be passed to the argument action when creating a new event, e.g., Event$new(name = 'interim', trigger_condition = TriggerByCalendarTime, action = do_nothing, calendar_time = 64).
TrialSimulator 0.30.0
New Features
Capture error inside Controller$run() and insert error message into output (see Trial$get_output()$error_message). It helps to integrate TrialSimulator with targets.
TrialSimulator 0.29.0
New Features
Support closed test based on inverse normal combination test.
Seed can be accessed by Trial$get_seed().
TrialSimulator 0.28.0
New Features
Support inverse normal combination test when multiple treatment arms present. Dunnett’s test is used for comparison.
Specify random seed if user dose not pick one. Seed is saved into Trial’s output for reproducibility.
TrialSimulator 0.27.0
New Features
Support dry run for fixed design.
TrialSimulator 0.26.0
New Features
Adjust boundary at final analysis for over- or under-running trials.
Support custom alpha spending function in graphical testing procedure.
TrialSimulator 0.25.0
New Features
Support inverse normal combination test for logrank statistics.
TrialSimulator 0.24.0
New Features
Update GraphicalTesting based on simplified interface of GroupSequentialTest.
